Residual noise covariance for Planck low-resolution data analysis

29 páginas, 16+6 figuras, 4 tablas.-- et al.[Aims]: We develop and validate tools for estimating residual noise covariance in Planck frequency maps, we also quantify signal error effects and compare different techniques to produce low-resolution maps. [Methods]: We derived analytical estimates of covariance of the residual noise contained in low-resolution maps produced using a number of mapmaking approaches. We tested these analytical predictions using both Monte Carlo simulations and by applying them to angular power spectrum estimation. We used simulations to quantify the level of signal errors incurred in the different resolution downgrading schemes considered in this work. [Results]: We find excellent agreement between the optimal residual noise covariance matrices and Monte Carlo noise maps. For destriping mapmakers, the extent of agreement is dictated by the knee frequency of the correlated noise component and the chosen baseline offset length. Signal striping is shown to be insignificant when properly dealt with. In map resolution downgrading, we find that a carefully selected window function is required to reduce aliasing to the subpercent level at multipoles, ℓ > 2Nside, where Nside is the HEALPix resolution parameter. We show that, for a polarization measurement, reliable characterization of the residual noise is required to draw reliable constraints on large-scale anisotropy. [Conclusions]: Methods presented and tested in this paper allow for production of low-resolution maps with both controlled sky signal error level and a reliable estimate of covariance of the residual noise. We have also presented a method for smoothing the residual noise covariance matrices to describe the noise correlations in smoothed, bandwidth-limited maps.Peer reviewe

Isocurvature fluctuations in Affleck-Dine mechanism and constraints on inflation models

We reconsider the Affleck-Dine mechanism for baryogenesis and show that the baryonic isocurvature fluctuations are generated in many inflation models in supergravity. The inflationary scale and the reheating temperature must satisfy certain constraints to avoid too large baryonic isocurvature fluctuations.Comment: 18 pages, 1 figur

Preparing for and Responding to Disturbance: Examples from the Forest Sector in Sweden and Canada

Coping or adaptation following large-scale disturbance may depend on the political system and its preparedness and policy development in relation to risks. Adaptive or foresight planning is necessary in order to account and plan for potential risks that may increase or take place concurrently with climate change. Forests constitute relevant examples of large-scale renewable resource systems that have been directly affected by recent environmental and social changes, and where different levels of management may influence each other. This article views disturbances in the forest sectors of Sweden and Canada, two large forest nations with comparable forestry experiences, in order to elucidate the preparedness and existing responses to multiple potential stresses. The article concludes that the two countries are exposed to stresses that indicate the importance of the governing and institutional system particularly with regard to multi-level systems including federal and EU levels. While economic change largely results in privatization of risk onto individual companies and their economic resources (in Canada coupled with a contestation of institutional systems and equity in these), storm and pest outbreaks in particular challenge institutional capacities at administrative levels, within the context provided by governance and tenure systems.In Sweden, funding from the research agency FORMAS, the MISTRA Arctic Futures programme, and the Future Forests programme (funded by research agency MISTRA, the forest industries, Umeå University and the Swedish University of Agricultural Sciences) as well as from the EU for data collection is acknowledged. Ryan Bullock acknowledges funding provided by the Social Sciences and Humanities Research Council and by the Mistra Arctic Futures programme for preparing this paper.https://www.mdpi.com/1999-4907/2/2/50

Planck early results XIX : All-sky temperature and dust optical depth from Planck and IRAS. Constraints on the “dark gas” in our Galaxy

Peer reviewe

IRF2BP2 Mutation Is Associated with Increased STAT1 and STAT5 Activation in Two Family Members with Inflammatory Conditions and Lymphopenia

Interferon regulatory factor 2 binding protein 2 (IRF2BP2) is a transcriptional coregulator that has an important role in the regulation of the immune response. IRF2BP2 has been associated with the Janus kinase (JAK)—signal transducers and activators of transcription (STAT) pathway, but its exact role remains elusive. Here, we identified a novel clinical variant, IRF2BP2 c.625_665del, from two members of a family with inflammatory conditions and investigated the function of IRF2BP2 and c.625_665del mutation in JAK–STAT pathway activation and inflammatory signaling. The levels of constitutive and cytokine-induced phosphorylation of STATs and total STAT1 in peripheral blood monocytes, T cells, and B cells from the patients and four healthy controls were measured by flow cytometry. Inflammation-related gene expression was studied in peripheral blood mononuclear cells using direct digital detection of mRNA (NanoString). Finally, we studied the relationship between IRF2BP2 and STAT1 activation using a luciferase reporter system in a cell model. Our results show that patients having the IRF2BP2 c.625_665del mutation presented overexpression of STAT1 protein and increased constitutive activation of STAT1. In addition, interferon-induced JAK–STAT signaling was upregulated, and several interferon-inducible genes were overexpressed. Constitutive phosphorylation of STAT5 was also found to be upregulated in CD4+ T cells from the patients. Using a cell model, we show that IRF2BP2 was needed to attenuate STAT1 transcriptional activity and that IRF2BP2 c.625_665del mutation failed in this. We conclude that IRF2BP2 has an important role in suppressing immune responses elicited by STAT1 and STAT5 and suggest that aberrations in IRF2BP2 can lead to abnormal function of intrinsic immunity

Planck 2013 results. VI. High Frequency Instrument data processing

Peer reviewe

IRF2BP2 Mutation Is Associated with Increased STAT1 and STAT5 Activation in Two Family Members with Inflammatory Conditions and Lymphopenia

Interferon regulatory factor 2 binding protein 2 (IRF2BP2) is a transcriptional coregulator that has an important role in the regulation of the immune response. IRF2BP2 has been associated with the Janus kinase (JAK)—signal transducers and activators of transcription (STAT) pathway, but its exact role remains elusive. Here, we identified a novel clinical variant, IRF2BP2 c.625_665del, from two members of a family with inflammatory conditions and investigated the function of IRF2BP2 and c.625_665del mutation in JAK–STAT pathway activation and inflammatory signaling. The levels of constitutive and cytokine-induced phosphorylation of STATs and total STAT1 in peripheral blood monocytes, T cells, and B cells from the patients and four healthy controls were measured by flow cytometry. Inflammation-related gene expression was studied in peripheral blood mononuclear cells using direct digital detection of mRNA (NanoString). Finally, we studied the relationship between IRF2BP2 and STAT1 activation using a luciferase reporter system in a cell model. Our results show that patients having the IRF2BP2 c.625_665del mutation presented overexpression of STAT1 protein and increased constitutive activation of STAT1. In addition, interferon-induced JAK–STAT signaling was upregulated, and several interferon-inducible genes were overexpressed. Constitutive phosphorylation of STAT5 was also found to be upregulated in CD4+ T cells from the patients. Using a cell model, we show that IRF2BP2 was needed to attenuate STAT1 transcriptional activity and that IRF2BP2 c.625_665del mutation failed in this. We conclude that IRF2BP2 has an important role in suppressing immune responses elicited by STAT1 and STAT5 and suggest that aberrations in IRF2BP2 can lead to abnormal function of intrinsic immunity

Planck early results XIII : Statistical properties of extragalactic radio sources in the Planck Early Release Compact Source Catalogue

Peer reviewe

Isocurvature modes and Baryon Acoustic Oscillations

The measurement of Baryonic Acoustic Oscillations from galaxy surveys is well known to be a robust and powerful tool to constrain dark energy. This method relies on the knowledge of the size of the acoustic horizon at radiation drag derived from Cosmic Microwave Background Anisotropy measurements. In this paper we quantify the effect of non-standard initial conditions in the form of an isocurvature component on the determination of dark energy parameters from future BAO surveys. In particular, if there is an isocurvature component (at a level still allowed by present data) but it is ignored in the CMB analysis, the sound horizon and cosmological parameters determination is biased, and, as a consequence, future surveys may incorrectly suggest deviations from a cosmological constant. In order to recover an unbiased determination of the sound horizon and dark energy parameters, a component of isocurvature perturbations must be included in the model when analyzing CMB data. Fortunately, doing so does not increase parameter errors significantly.Comment: 23 pages, 3 figure

Planck early results XVI : The Planck view of nearby galaxies

Peer reviewe